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The Science - Clinical Trials and References

Studies:

#
First author, year (journal)
Key finding (dose / model)
Free full-text / DOI
1 Inoue 2016 (J Sci Food Agric) 5 g day⁻¹ “NGI” bovine HC for 8 weeks ↑ skin hydration (+7-12 %), elasticity (+4-9 %), ↓ wrinkle depth (-8 %) in 56 women (DB-RCT). PubMed: https://pubmed.ncbi.nlm.nih.gov/26840887 Europe PMC
2 Ohara 2007 (J Agric Food Chem) Human crossover study (5 ♂) showed plasma peak 20-60 nmol mL⁻¹ Hyp-di/tripeptides 1-2 h after 10 g bovine HC. https://pubmed.ncbi.nlm.nih.gov/17253720 Europe PMC
3 Iwai 2005 (J Agric Food Chem) First identification of food-derived Pro-Hyp in human blood after 10 g porcine/bovine HC; proves intact tripeptide absorption. https://pubmed.ncbi.nlm.nih.gov/16076145 Europe PMC
4 Ichikawa 2010 (Int J Food Sci Nutr) 9 g day⁻¹ bovine HC for 4 weeks: plasma Pro-Hyp 4-fold ↑; confirms dose-dependence of tripeptide appearance. https://pubmed.ncbi.nlm.nih.gov/19961355 Europe PMC
5 Watanabe-Kamiyama 2010 (J Agric Food Chem) Rats given low-MW bovine HC (average 3 kDa): ↑ femoral bone mineral content (+7 %). https://pubmed.ncbi.nlm.nih.gov/19957932 Europe PMC
6 Yamamoto 2016 (Biol Pharm Bull) Human study comparing purified CTP-50 vs generic HC: plasma & urinary Pro-Hyp ↑ proportional to Gly-Pro-Hyp intake. https://pubmed.ncbi.nlm.nih.gov/26934933 Europe PMC
7 Proksch 2014 – VERISOL® (Skin Pharmacol Physiol) 2.5 g bovine-hide BCP for 8 weeks ↓ eye-wrinkle volume by -20 %; procollagen I +65 %. https://pubmed.ncbi.nlm.nih.gov/24401291 Europe PMC
8 Proksch 2013 (Skin Pharmacol Physiol) 2.5 or 5 g bovine HC for 8 weeks ↑ skin elasticity 15 %; effect persisted 4 weeks post-intervention. https://pubmed.ncbi.nlm.nih.gov/23949208 Europe PMC
9 Song 2013 (Clin Interv Aging) 3 g collagen tripeptide for 12 weeks ↑ skin hydration (+28 %) & elasticity (+19 %) in healthy adults. https://pubmed.ncbi.nlm.nih.gov/24131075 Europe PMC
10 Hexsel 2017 (J Cosmet Dermatol) 2.5 g bovine BCP × 24 weeks: ↑ nail growth rate (+12 %) & ↓ fragility (-42 %). https://pubmed.ncbi.nlm.nih.gov/28786550 Europe PMC

Summaries:

#
Study & model
What they measured
Direction of the main result
1 Inoue 2016 – 8-week DB-RCT, 56 women, 5 g/day bovine HC Corneometer skin hydration, Cutometer elasticity, fringe-projection wrinkle depth ↑ Hydration (+7-12 %), ↑ elasticity (+4-9 %), ↓ wrinkle depth (-8 %) vs placebo ndlabs.com
2 Ohara 2007 – single-dose crossover PK, 5 men, 10 g bovine HC Plasma levels of Hyp-di/tri-peptides Peaks of 20-60 nmol mL-¹ Pro-Hyp/Hyp-Gly at 1-2 h post-dose (none at baseline) Europe PMC
3 Iwai 2005 – single-dose PK, 5 volunteers, 10 g porcine/bovine HC Identification of intact tripeptides in serum First proof of Pro-Hyp appearance in human blood after oral collagen (positive mechanistic outcome) skinglow.com.ar
4 Ichikawa 2010 – dose-escalation PK, 4 volunteers Dose-response of plasma Hyp-peptides (30–385 mg kg-¹) Clear, linear ↑ in peptide Cmax with higher doses (6 → 33 nmol mL-¹) Europe PMC
5 Watanabe-Kamiyama 2010 – ovariectomised-rat model, 4 wks LMW bovine HC Femoral bone organic content & BMC ↑ Bone organic matter and BMC (+7 %) vs controls; protective against osteoporosis Medscape
6 Yamamoto 2016 – human crossover, 9 subjects, tripeptide-enriched CTP vs generic HC Plasma & urinary Gly-Pro-Hyp/Pro-Hyp Higher and longer-lasting peptide levels with CTP-50; magnitude proportional to tripeptide dose JSTAGE
7 Proksch 2014 – 114 women, 2.5 g VERISOL® for 8 wks 3-D stereo wrinkle volume & dermal biopsies -20 % eye-wrinkle volume; +65 % procollagen-I vs placebo (p < 0.05) Europe PMC
8 Proksch 2013 – 69 women, 2.5 / 5 g collagen peptides for 8 wks Cutometer elasticity (R2) +15 % elasticity at both doses; effect persisted 4 wks after stopping Europe PMC
9 Song 2013 (Kim BJ) – 64 adults, 3 g collagen tripeptide 12 wks Hydration & elasticity vs control +28 % hydration, +19 % elasticity; both significant vs control Europe PMC
10 Hexsel 2017 – 25 women, 2.5 g VERISOL® 24 wks (open-label) Nail growth rate & brittleness +12 % growth rate, -42 % cracked/brittle nails; 64 % “overall improvement” by physician assessment Europe PMC